C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) A61K 38/46 (2006.01) A61K 48/00 (2006.01) A61P 1/16 (2006.01) A61P 1/18 (2006.01) A61P 31/00 (2006.01) C12N 9/16 (2006.01) C12N 9/20 (2006.01) C12Q 1/34 (2006.01) G01N 33/48 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2355468
Glycosyl phosphatidy linositol specific phospholipase D (GPI-PLD) proteins and their medical uses are disclosed, in particular in the treatment and diagnosis of diabetes and complications of diabetes such as insulin resistance, liver dysfunction, disorders involving pancreatectomies and conditions mediated by a product of an infectious organism which is capable of inhibiting GPI-PLD, such as septic shock. The present invention further relates to variant GPI-PLD polypeptides modified at the phosphorylation site at amino acids 689-692 of the mature human wild-type protein.
L'invention se rapporte à des protéines D phospholipase spécifiques du glycosyl phosphatidy linositol (GPI-PLD) ainsi qu'à leurs utilisations médicales, notamment pour le traitement et le diagnostic du diabète et des complications du diabète, telles que la résistance à l'insuline, les dysfonctionnements du foie, les troubles impliquant une pancréatectomie et les états pathologiques dont la médiation est assurée par un produit d'organisme infectieux qui est susceptible d'inhiber la GPI-PLD, du type choc septique. La présente invention se rapporte également à des polypeptides variants de GPI-PLD modifiés au niveau du site de phosphorylation sur les acides aminés 689-692 de la protéine mature, humaine du type sauvage.
Rademacher Thomas William
Schofield Julian
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sylus Pharmaceuticals Ltd
University College London
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