Glycosyl sulfotransferase-3

Details Glycosyl sulfotransferase-3 Glycosyl sulfotransferase-3

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) A01K 67/027 (2006.01) A61K 38/45 (2006.01) A61K 39/395 (2006.01) C07H 21/04 (2006.01) C07K 16/40 (2006.01) C12N 1/14 (2006.01) C12N 1/20 (2006.01) C12N 1/21 (2006.01) C12N 5/00 (2006.01) C12N 5/10 (2006.01) C12N 9/00 (2006.01) C12N 9/10 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2322779

Novel mammalian glycosylsulfotransferases expressed in high endothelial cells (GST-3) and polypeptides related thereto, as well as nucleic acid compositions encoding the same, are provided. The subject polypeptides and nucleic acid compositions find use in a variety of applications, including research, diagnostic, and therapeutic agent screening applications. Also provided are methods of inhibiting selectin mediated binding events and methods of treating disease conditions associated therewith, particularly by administering an inhibitor of at least one of GST-3 or KSGal6ST, or homologues thereof.

L'invention concerne de nouvelles glycosylsulfotransférases mammifères exprimées dans des cellules endothéliales spéciales (GST-3) et des polypeptides apparentés, ainsi que des compositions d'acides nucléiques les codant. Ces polypeptides et ces compositions d'acides nucléiques peuvent être mis en application dans une variété de domaines, y compris la recherche, le diagnostic et la détection d'agents thérapeutiques. Elle concerne également des procédés permettant d'inhiber des épisodes de fixation par l'intermédiaire de sélectine et des procédés servant à traiter des maladies associées à ceux-ci, en particulier par administration d'un inhibiteur d'au moins un de GST-3 ou KSGal6ST ou de leurs homologues.

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