Glycosylated fgf and production thereof

Details Glycosylated fgf and production thereof Glycosylated fgf and production thereof

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/50 (2006.01) C12N 1/00 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2015313

TITLE: GLYCOSYLATED FGF AND PRODUCTION THEREOF ABSTRACT Disclosed are (1) a mutein of a fibroblast growth factor (FGF), the DNA having introduced therein at least one nucleotide sequence coding for a glycosylation site, (2) a DNA coding for the mutein of (1), (3) a vector containing the DNA of (2), (4) a transformant transformed with the vector of (3), and (5) a process for producing the mutein which comprises cultivating in a culture medium the transformant of a yeast or animal cell transformed with a vector of (3), and producing and accumulating the mutein of (1) in the culture medium, whereby the FGF mutein into which at least one glycosylation site has been introduced is improved in productivity, stability and activities, and advantageously used as medicine.

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