Glycosylated humanized b-cell specific antibodies

Details Glycosylated humanized b-cell specific antibodies Glycosylated humanized b-cell specific antibodies

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/46 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2249320

A humanized specific monoclonal antibody or antibody fragment, especially a B- cell specific antibody or antibody fragment, is engineered to contain a glyxosylation site in the non-Fc constant region. The glycosylated antibody is useful for diagnosis and/or therapy whenever a targeting antibody or fragment is used, especially for B-cell malignancies. The carbohydrate moiety allows conjugation of labeling or therapeutic agents of increased size, without affecting the binding affinity or specificity of the antibody.

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