Glycosylated il-7, preparation and uses

Details Glycosylated il-7, preparation and uses Glycosylated il-7, preparation and uses

C - Chemistry, Metallurgy

12

N

C12N 15/24 (2006.01) A61K 38/20 (2006.01) C07K 14/54 (2006.01) C07K 14/715 (2006.01)

Patent

CA 2615562

The present invention relates to new and improved interleukin-7 polypeptides, as well as compositions comprising the same, their preparation and uses. The invention more particularly relates to hyperglycosylated IL-7 polypeptides having improved properties, as well as their manufacture and therapeutic uses. The invention also discloses novel IL-7 polypeptides having modified amino acid sequences containing artificially created glycosylation site(s), as well as corresponding nucleic acid molecules, vectors and recombinant host cells. The invention also relates to the use of such polypeptides, cells or nucleic acids for curative or preventive treatment of mammalian subjects, including human subjects.

Cette invention concerne des polypeptides d'interleukine-7 nouveaux et améliorés, ainsi que des compositions comprenant ces polypeptides, leur préparation et leurs utilisations. Cette invention concerne plus particulièrement des polypeptides IL-7 hyperglycosylés présentant des propriétés améliorées, ainsi que leur fabrication et leurs utilisations thérapeutiques. Cette invention concerne également de nouveaux polypeptides IL-7 comprenant des séquences d'acides aminés modifiées contenant un ou plusieurs sites de glycosylation créés artificiellement, ainsi que des molécules d'acides nucléiques, des vecteurs et des cellules hôtes recombinantes correspondants. Cette invention concerne également l'utilisation de tels polypeptides, cellules ou acides nucléiques en vue d'un traitement curatif ou préventif de sujets mammifères, y compris de sujets humains.

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