Glycosylated insulin derivatives

Details Glycosylated insulin derivatives Glycosylated insulin derivatives

C - Chemistry, Metallurgy

07

K

530/9

C07K 14/62 (2006.01) C07H 15/203 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1216578

ABSTRACT OF THE DISCLOSURE Synthesized succinyl and glutaryl glucosamines, p-(succinylamido)- phenyl-.alpha.-D-gluco- and mannopyranosides, p-(glutarylamido)-phenyl-.alpha.-D- gluco- and mannopyranosides and p-(isothiocyanotophenyl)- .alpha.-D-gluco- and mannopyranosides are reacted with insulin to form corresponding glycosylated insulins containing from 1 to 3 glycosyl groups per insulin molecule. The novel glycosylated insulins resist aggregation and show significant activity in depressing blood sugar levels.

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