Glycosylated leptin compositions and related methods

Details Glycosylated leptin compositions and related methods Glycosylated leptin compositions and related methods

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A61K 38/22 (2006.01) A61P 3/04 (2006.01) A61P 3/06 (2006.01) A61P 5/48 (2006.01) C07K 14/575 (2006.01) C07K 16/26 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2359840

The present invention relates to glycosylated leptin compositions and related methods. Included are glycosylated leptin proteins having a Stokes' radius allowing for improved properties, as well as glycosylated leptin proteins having selected sites for glycosylation, nucleic acids encoding such proteins, related host cells, vectors, processes for production, and methods of use of such compositions. Novel methods of producing glycosylated proteins are also provided. The glycolysated leptin protein can be used for preparing a pharmaceutical composition that can be used in the treatment of a human for a condition selected among obesity, diabetes and high blood lipid content.

L'invention concerne des compositions glycosylées de leptine et les procédés correspondants. L'invention concerne également des protéines glycosylées de leptine présentant un rayon de Stokes qui permet l'amélioration de leurs propriétés, ainsi que des protéines glycosylées de leptine possédant des sites sélectionnés pour la glycosylation, des acides nucléiques codant pour ces protéines, des cellules hôtes associées, des vecteurs, des processus de production, et des procédés d'utilisation de ces compositions. L'invention concerne, en outre, de nouveaux procédés de production de protéines glycosylées. Les protéines glycosylées de leptine peuvent être utilisées pour préparer une composition pharmaceutique servant à traiter un humain contre des troubles tels que l'obésité, les diabètes, et les troubles associés à un taux de lipides élevé dans le sang.

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