Glycosylation-deficient hepatocyte growth factor

Details Glycosylation-deficient hepatocyte growth factor Glycosylation-deficient hepatocyte growth factor

C - Chemistry, Metallurgy

07

K

C07K 14/52 (2006.01) A61K 31/711 (2006.01) A61K 48/00 (2006.01) A61P 1/04 (2006.01) A61P 1/16 (2006.01) A61P 7/00 (2006.01) A61P 9/00 (2006.01) A61P 11/00 (2006.01) A61P 13/12 (2006.01) A61P 17/02 (2006.01) A61P 19/08 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C12N 15/19 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2549878

It is intended to provide a modification lacking a sugar chain of HGF and a process for producing the same. A sugar chain-lacking hepatocyte growth factor wherein a mutation has been transferred into at least one sugar chain- attachment site in the amino acid sequence of hepatocyte growth factor so as to prevent the attachment of a sugar chain.

L'invention vise à fournir une modification du facteur de croissance hépatocyte en enlevant la chaîne de sucre ainsi que son procédé d'obtention. Une mutation a été transférée dans au moins un site de fixation de chaîne de sucre dans la séquence d'acides aminés du facteur de croissance hépatocyte de manière à éviter la fixation d'une chaîne de sucre.

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