A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C07K 16/00 (2006.01) C12P 21/00 (2006.01) C12P 21/08 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2655246
The instant invention is drawn to methods of generating a glycosylation- engineered antibody, and using the glycosylation-engineered antibody for treating a patient, particularly a cancer patient or a patient with an immune disease or disorder. The instant invention is also drawn to methods of generating a glycosylation-engineered antibody for use in the treatment of patients having a polymorphism that does not respond to conventional antibody therapy. The instant invention is also drawn to methods of improving the biological activity of an antibody by glycosylation engineering. The instant invention is also drawn to methods of modulating antibody-dependent cell-mediated cytoxicity (ADCC) using a glycosylation- engineered antibody.
La présente invention concerne des procédés permettant de générer un anticorps modifié par glycosylation ainsi que l'utilisation de cet anticorps modifié par glycosylation pour traiter un patient, en particulier un patient cancéreux ou un patient atteint d'une maladie ou d'un trouble immunitaire. L'invention concerne également des procédés permettant de générer un anticorps modifié par glycosylation en vue de l'utiliser dans le traitement de patients présentant un polymorphisme qui ne réagit pas à la thérapie avec un anticorps classique. Elle concerne en outre des procédés permettant d'améliorer l'activité biologique d'un anticorps en le modifiant par glycosylation. Enfin, elle concerne des procédés permettant de moduler la cytotoxicité cellulaire anticorps-dépendante (ADCC) en utilisant un anticorps modifié par glycosylation.
Strome Scott
Wang Lai-Xi
Gowling Lafleur Henderson Llp
University Of Maryland Baltimore
University Of Maryland - Biotechnology Institute
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