Glycosylation-mediated inhibition of factor x

Details Glycosylation-mediated inhibition of factor x Glycosylation-mediated inhibition of factor x

C - Chemistry, Metallurgy

12

N

C12N 9/48 (2006.01) A61K 38/43 (2006.01) A61K 38/47 (2006.01) A61K 38/48 (2006.01) A61K 38/55 (2006.01) A61K 39/395 (2006.01) C07K 14/42 (2006.01) C07K 14/745 (2006.01) C07K 16/36 (2006.01) C12N 9/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2132518

2132518 9318782 PCTABS00025 Reagents that specifically bind a carbohydrate target wherein sialic acid is linked at the nonreducing terminus of a glycoside to a galactose or galactosamine residue through an .alpha.2-6 linkage are able to inhibit the conversion of human Factor X to human Factor Xa. These reagents (SA/Gal/GalNAc binding reagents) as well as other strategies for inhibiting the conversion of Factor X to Factor Xa are useful in treating thrombosis, inflammation and other conditions associated with excess thrombin activity.

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