C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/775 (2006.01) A61K 31/00 (2006.01) A61K 31/155 (2006.01) A61K 31/195 (2006.01) A61K 31/415 (2006.01) A61K 31/70 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01) G01N 33/92 (2006.01) A61K 7/48 (1995.01)
Patent
CA 2157865
The in vivo oxidation of lipids and lipid-containing molecules has been discovered to be initiated by the reaction of such lipid materials with reducing sugars such as glucose, advanced glycosylation endproducts such as AGE-peptides, or a compound which forms advanced glycosylation endproducts, to form materials or particles known as AGE-lipids. AGE-lipids have been implicated in the aging process, the abnormal formation of lipofuscin and invarious disease states such as diabetes and atherosclerosis. Diagnostic methods are contemplated, extending in utility from the detection of the onset and course of conditions in which variations in lipid oxidation, AGE-lipid levels, LDL levels, apolipoprotein levels, apolipoprotein receptor binding the like, may be measured, to drug discovery assays. Corresponding methods of treatment and pharmaceutical compositions are disclosed that are based on an active ingredient or ingredients that demonstrate the ability to modulate the levels of all the foregoing markers of lipid oxidation.
Anthony Cerami
Bucala Richard J.
Vlassara Helen
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Picower Institute For Medical Research
LandOfFree
Glycosylation of lipids and lipid-containing particles, and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Glycosylation of lipids and lipid-containing particles, and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Glycosylation of lipids and lipid-containing particles, and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1601652