Glycosylation variants of ricin-like proteins

Details Glycosylation variants of ricin-like proteins Glycosylation variants of ricin-like proteins

C - Chemistry, Metallurgy

12

N

C12N 15/29 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01) C07K 14/415 (2006.01)

Patent

CA 2560636

The present invention provides glycosylation variants of recombinant proteins and nucleic acids that encode such recombinant proteins, which are useful as therapeutics against cancer, and viral, parasitic and fungal infections. The proteins and nucleic acids have A and B chains of ricin-like toxin linked by a linker sequence that is specifically cleaved and activated by proteases specific to disease-associated pathogens or cells. The invention also relates to methods of inhibiting or destroying cells affected by a disease, methods of treating a mammal with a disease, and pharmaceutical compositions using the recombinant proteins and nucleic acids of the invention.

La présente invention porte sur des variants de glycosylation de protéines de recombinaison et sur des acides nucléiques codant ces protéines de recombinaison pouvant être utilisés comme agents thérapeutiques contre le cancer et les infections virales, parasitaires et fongiques. Les protéines et les acides nucléiques comportent des chaînes A et B de toxine de type ricine liées par une séquence de liaison qui est spécifiquement clivée et activée par des protéases spécifiques de pathogènes ou de cellules associés à une maladie. Cette invention concerne également des méthodes permettant d'inhiber ou de détruire les cellules affectées par une maladie, des méthodes de traitement d'un mammifère malade, ainsi que des compositions pharmaceutiques utilisant les protéines de recombinaison et les acides nucléiques de cette invention.

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