Glycosyltransferase gnt-v having neovascularization action

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/54 (2006.01) A61K 38/17 (2006.01) C07K 14/515 (2006.01) C12N 9/10 (2006.01) C12N 15/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2472381

A peptide or a protein having an angiogenic effect and containing the basic amino acid cluster region of .beta.1,6-N-aetylglucosaminyl transferase; an angiogenesis promoter containing the above peptide or protein; a method of screening a substance inhibiting the above peptide or protein; and an angiogenesis inhibitor containing the above inhibitory substance.

L'invention concerne un peptide ou une protéine présentant un effet angiogénique et contenant la zone de regroupement d'acides aminés de base de la .beta.1 ,6-N-aetylglucosaminyl transférase. L'invention traite aussi d'un promoteur d'angiogénèse contenant le peptide ou la protéine susmentionnés. L'invention a aussi pour objet un procédé de détection d'une substance inhibant le peptide ou la protéine susmentionnés. Enfin, l'invention concerne un inhibiteur d'angiogénèse contenant la substance inhibitrice susmentionnée.

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