C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) A61K 31/739 (2006.01) A61K 39/106 (2006.01) C12N 1/20 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/10 (2006.01) C12N 15/63 (2006.01) C12P 19/44 (2006.01) C12Q 1/68 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2377427
Novel isolated polynucleotides encoding glycosyltransferases involved in the biosynthesis of the lipopolysaccharide of Helicobacter pylori, together with recombinant DNA constructs and vectors containing polynucleotide sequences encoding such glycosyltransferases are disclosed. These nucleic acid constructs and vectors may be used for the preparation of glycosyltransferases they encode, by expressing the coding polynucleotide sequences in suitable host cells. Also disclosed are isolated polypeptides having enzymatic activity of helicobacterial glycosyltransferases. Such polypeptides are particularly useful for screening of modulators of their enzymatic activity, in particular enzymatic inhibitors having potential antibacterial activity.
L'invention concerne de nouveaux polynucléotides isolés codant pour les glycosyltransférases participant à la biosynthèse du lipopolysaccharide de Helicobacter pylori ainsi que des structures d'ADN et des vecteurs recombinants contenant des séquences polynucléotidiques codant pour ces glycosyltransférases. Ces structures d'acides nucléiques et vecteurs peuvent être utilisés dans la préparation des glycosyltransférases pour lesquelles elles codent au moyen de l'expression des séquences polynucléotidiques codantes dans des cellules cibles appropriés. L'invention concerne aussi des polypeptides isolés possédant l'activité enzymatique des glycosyltransférases de Helicobacter. Ces polypeptides sont particulièrement utiles pour cribler les modulateurs de leur activité enzymatique, notamment les inhibiteurs enzymatiques possédant une éventuelle activité antibactérienne.
Altman Eleonora
Conlan Wayne
Hiratsuka Koji
Logan Susan M.
Monteiro Mario A.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
National Research Council Of Canada
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