C - Chemistry – Metallurgy – 07 – J
Patent
C - Chemistry, Metallurgy
07
J
C07J 63/00 (2006.01) A61K 31/56 (2006.01) A61K 31/575 (2006.01) A61K 49/00 (2006.01) A61P 3/10 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) C07J 53/00 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2653726
The present invention relates to novel derivatives of glycyrrhetimc acid of Formula (I), compositions comprising said derivatives and their use in the treatment of conditions or diseases that benefit from an upregulation of PPAR.gamma. and/or a downregulation of the expression or activity of one or more specificity (Sp) proteins, such as cancer, diabetes and Huntmgton's disease.
La présente invention concerne de nouveaux dérivés de l'acide glycyrrhétinique de formule (I), des compositions comprenant lesdits dérivés et l'utilisation de ceux-ci dans le traitement d'affections ou maladies, telles que le cancer, le diabète et la maladie de Huntington, qui bénéficient d'une régulation à la hausse du PPAR.gamma. et/ou d'une régulation à la baisse de l'expression ou de l'activité d'une ou plusieurs protéines de spécificité (Sp).
Chintharlapalli Sudhakar
Mcalees Alan
Mccrindle Robert
Safe Stephen H.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Chintharlapalli Sudhakar
Mcalees Alan
Mccrindle Robert
Safe Stephen H.
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