Glyt1 transgenic mice

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A01K 67/027 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2497818

The present invention provides genetic constructs and methods for producing transgenic non-human animals comprising within their genome transgenic DNA encoding GLYT1. These transgenic animals could be further used to generate transgenic animals which produce more active GLYT1. Moreover, said transgenic animals producing more GLYT1 protein, as well as the methods of producing them are also provided. The invention also relates to the use of these animals as a model for analyzing the effects of depressing synaptic NMDA receptor function and studying the ability of compounds to reduce symptoms of psychotic behavior.

La présente invention porte sur des constructions génétiques et des méthodes permettant de produire des animaux transgéniques non humains ayant dans leur génome un ADN transgénique codant la protéine GLYT1. Ces animaux transgéniques peuvent être utilisés pour produire des animaux transgéniques fabriquant une protéine GLYT1 plus active. En outre, l'invention concerne aussi lesdits animaux transgéniques produisant une plus grande quantité de protéine GLYT1, de même que les méthodes permettant de les produire. L'invention traite aussi de l'utilisation de ces animaux comme modèle pour l'analyse des effets d'une dépression des récepteurs NMDA de la synapse et l'étude de l'efficacité de ces composés à réduire les symptômes associés au comportement psychotique.

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