Gm-negative ehv-mutants

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/27 (2006.01) C07K 14/03 (2006.01) C12N 7/04 (2006.01) C12N 15/38 (2006.01) C12N 15/869 (2006.01)

Patent

CA 2399846

This invention relates to Equine Herpes Viruses (EHV) wherein the protein gM is essentially absent or modified and non-functional with respect to its immunomodulatory capacity. Further aspects of the invention relate to nucleic acids coding said viruses, pharmaceutical compositions comprising these viruses or nucleic acids and uses thereof. The invention also relates to methods for improving the immune response induced by an EHV vaccine against wild type EHV infections, methods for the prophylaxis and treatment of EHV infections and methods for distinguishing wild type EHV infected animals from animals treated with EHV's according to the invention.

La présente invention concerne des virus herpétiques équins (EHV) dans lesquels la protéine gM est sensiblement absente ou modifiée et non fonctionnelle par rapport à sa capacité immunomodulatoire. L'invention concerne également des acides nucléiques codant pour ces virus, des compositions pharmaceutiques renfermant ces virus ou ces acides nucléiques et des utilisations de ceux-ci. L'invention concerne en outre des procédés permettant d'améliorer la réponse immune induite par un vaccin EHV contre des infections à virus EHV du type sauvage, des procédés de prophylaxie et de traitement des infections à virus EHV ainsi que des procédés permettant de distinguer des animaux infectés par des virus EHV du type sauvage des animaux traités avec des virus EHV selon l'invention.

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