Gnrh antagonists

Details Gnrh antagonists Gnrh antagonists

C - Chemistry, Metallurgy

07

K

530/7.06

C07K 7/23 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1262399

GnRH ANTAGONISTS ABSTRACT OF THE DISCLOSURE Peptides which inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads. Administration of an effective amount prevents ovulation of female mammalian eggs and/or the release of steroids by the gonads. The peptides have the structure: X-R1-R2-R3-Ser-R5-R6-R7-Arg-Pro-R10 wherein X is hydrogen, Acr or Ac; R1 is .beta.-D-2NAL, dehydroPro or 4Cl-D-Phe; R2 is Cl-D-Phe, F-D-Phe or C.alpha.Me-Cl-D-Phe; R3 is D-Trp or .beta.-D-2NAL; R5 is Arg or D-Arg; R6 is D-Tyr, .beta.-D-2NAL or D-Arg; R7 is Leu or NML; and R10 is Gly-NH2, NHCH2CH3 or D-Ala-NH2.

467930

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