Gnrh antagonists ii

Details Gnrh antagonists ii Gnrh antagonists ii

C - Chemistry, Metallurgy

07

K

530/7.06

C07K 7/06 (2006.01) C07K 7/23 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1263500

GnRH ANTAGONISTS II ABSTRACT OF THE DISCLOSURE Peptides which inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads. Administration of an effective amount prevents ovulation of female mammalian eggs and/or the release of steroids by the gonads. The peptides have the structure: X-.beta.-D-2NAL-R2-D-Trp-Ser-Tyr-R6-R7-Arg-Pro-R10 wherein X is hydrogen or an acyl group having 7 or less carbon atoms; R2 is Cl-D-Phe, F-D-Phe, NO2-D-Phe, Cl2-D-Phe or Br-D-Phe; R6 is 4-NH2-D-Phe or D-Arg; R7 is Leu or N.alpha.Me-Leu; and R10 is Gly-NH2, NHCH2CH3 or D-Ala-NH2.

433229

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