Gnrh antagonists viii

Details Gnrh antagonists viii Gnrh antagonists viii

C - Chemistry, Metallurgy

07

K

530/7.2

C07K 7/23 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1302650

GnRH ANTAGONISTS VII ABSTRACT OF THE DISCLOSURE Peptides which inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads. Administration of an effective amount prevents ovulation of female mammalian eggs and/or the release of steroids by the gonads. The peptides have the structure: X-R1-(W)D-Phe-R3-R4- R5-R6-R7-Arg-Pro-R10 wherein X is hydrogen or an acyl group having 7 or less carbon atoms; R1 is dehydro-Pro, D-pGlu, D-Phe, 4Cl-D-Phe, D-Trp, Pro, or B-D-NAL; W is Cl, F, NO2, C?Me/4Cl, Cl2 or Br; R3 is D-3PAL, B-D-NAL or (Y)D-Trp, with Y being H, NO2, NH2, OCH3, F, Cl, Br, CH3, NinFor or NinAc; R4 is Ser, Orn, AAL or aBu; R5 is Tyr, Arg, (3F)Phe, (2F)Phe, (3I)Tyr, (3CH3)Phe, (2CH3)Phe, (3Cl)Phe or (2Cl)Phe; R6 is a D-isomer of a lipophilic amino acid or is 4-NH2-D-Phe, D-Lys, D-Orn, D-Har, D-His, 4-gua-D-Phe, D-PAL or D-Arg; R7 is Nle, Leu, NML, Phe, Met, Nva, Tyr, Trp, Cys, PAL or 4F-D-Phe; and R10 is Gly-NH2 D-Ala-NH2 or NH-Y', with Y' being lower alkyl, cycloalkyl, fluoro lower alkyl or NHCONH-Q, where Q is H or lower alkyl, provided however that when R3 is D-PAL, R5 is Arg and that when R3 is either B-D-NAL or D-Trp, then R7 is Tyr, PAL, Phe or 4F-D-Phe.

479605

Affiliated with

Also associated with

Rating

Gnrh antagonists viii does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Gnrh antagonists viii, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Gnrh antagonists viii will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1247945