Gnrh/reduced pseudomonas exotoxin conjugates

Details Gnrh/reduced pseudomonas exotoxin conjugates Gnrh/reduced pseudomonas exotoxin conjugates

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/09 (2006.01) A61K 39/385 (2006.01) A61K 47/48 (2006.01) C07K 7/23 (2006.01) C07K 14/21 (2006.01)

Patent

CA 2235510

Conjugates of GnRH are constructed from GnRH or an analog thereof, a reduced Pseudomonas exotoxin, or a variant thereof, and a unique linking group. The conjugates are administered to male and female animals to sterilize said animals or to reduce tumors that require sex steroids for growth. The instant conjugates are therefore useful as sterilizing agents and anticancer agents.

Des conjugués de GnRH (hormones libérant l'hormone lutéinisante) sont construits à partir de GnRH ou d'un analogue de celle-ci, à partir d'une exotoxine de Pseudomonas réduite ou d'un variant de cell-ci, et à partir d'un groupe de liaison unique. Ces conjugués sont administrés à des animaux mâles et femelles pour les stériliser ou pour réduire les tumeurs qui ont besoin de stéroïdes sexuels pour croître. Ces conjugués sont par conséquent utiles comme agents stérilisants et comme agents anticancéreux.

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