Gonadoliberin antagonists

Details Gonadoliberin antagonists Gonadoliberin antagonists

C - Chemistry, Metallurgy

07

K

C07K 7/23 (2006.01) A61K 38/09 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2048407

Peptides of the formula 1 2 3 4 5 6 7 8 9 10 X - A - B - C - Ser - D - E - F - G - Pro - H in which X is alkanoyl, A is optionally substituted D-Nal(2), D-Phe or D-Trp, B is optionally substituted D-Phe, C is D-Pal(3) or optionally substituted D-Phe or D- Trp, and D is Tyr or His, E is D-Ser (R1), F is Leu, Trp or Phe, G is L- Ser(R1), H is Gly-NH2, D-Ala-NH2 or Azagly-NH2 and R1 is a glycosyl radical have an inhibitory effect on the formation of the gonadotropins lutropin and follitropin and thus also on the synthesis of testo-sterone and estrogen. A process for the preparation of these peptides is described.

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