C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/7.2, 167/103
C07K 7/23 (2006.01) C07K 5/02 (2006.01) C07K 7/02 (2006.01) A61K 38/00 (2006.01)
Patent
CA 1258150
GONADOLIBERINE DERIVATIVES CONTAINING A 3-ASPARTYL GROUP, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM Abstract The invention relates to novel gonadoliberine derivatives of the general formula (I) 1 2 3 4 5 6 7 8 9 10 Image (I) wherein X represents an -O-R group wherein R is a benzyl group or a C1-4 alkyl group, an Image group wherein R1 and R2 independently stand for hydrogen, a C1-5 alkyl, aryl, aryl-C1-2-alkyl, morpholino, 1-indolinyl or 1-pyrrolidinyl group, Y is a glycine amide or a C1-4-alkyl-amide group, the addition salts thereof formed with acids used in therapy and complexes thereof as well as pharmaceutical compositions containing them, furthermore to a process for the preparation of the above compounds. The reproductive processes of vertebrates can be advantageously influenced with the compounds of general formula (I).
450712
Erchegyi Judit
Mezo Imre
Seprodi Janos
Teplan Istvan
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt
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