Gonadoliberin derivatives containing a .beta.-aspartyl...

C - Chemistry – Metallurgy – 07 – K

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530/7.2, 167/103

C07K 7/23 (2006.01) C07K 5/02 (2006.01) C07K 7/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1258150

GONADOLIBERINE DERIVATIVES CONTAINING A 3-ASPARTYL GROUP, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM Abstract The invention relates to novel gonadoliberine derivatives of the general formula (I) 1 2 3 4 5 6 7 8 9 10 Image (I) wherein X represents an -O-R group wherein R is a benzyl group or a C1-4 alkyl group, an Image group wherein R1 and R2 independently stand for hydrogen, a C1-5 alkyl, aryl, aryl-C1-2-alkyl, morpholino, 1-indolinyl or 1-pyrrolidinyl group, Y is a glycine amide or a C1-4-alkyl-amide group, the addition salts thereof formed with acids used in therapy and complexes thereof as well as pharmaceutical compositions containing them, furthermore to a process for the preparation of the above compounds. The reproductive processes of vertebrates can be advantageously influenced with the compounds of general formula (I).

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