Gonadotropic hormone originating in invertabrate and method...

Details Gonadotropic hormone originating in invertabrate and method... Gonadotropic hormone originating in invertabrate and method...

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) C07K 14/575 (2006.01) C07K 19/00 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2578136

[PROBLEMS] To clarify the structure of a gonadotropic hormone of an invertebrate (Asterina pectinifera). [MEANS FOR SOLVING PROBLEMS] This gonadotropic hormone is a peptide being composed of two subunits, having a molecular weight of from 4500 to 4900 and having a structure wherein these two subunits are bonded via an SS-crosslinkage between SH residues in cysteines contained in them.A peptide having a gonadotropic activity (a gonadotropic hormone) can be obtained by synthesizing these two subunits, mixing them and oxidizing.

Cette invention a pour objectif de clarifier la structure d'une hormone gonadotrope d'un invertébré (<i>Asterina pectinifera</i>). Cette hormone gonadotrope est un peptide composé de deux sous unités, ayant une masse moléculaire allant de 4500 à 4900 et une structure où ces deux sous unités sont liées par une réticulation SS entre les résidus SH dans les cystéines contenues dans ces derniers. Un peptide ayant une activité gonadotrope (une hormone gonadotrope) peut être obtenu en synthétisant ces deux sous unités, en les mélangeant et en les oxydant.

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