C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/505 (2006.01) A61P 5/02 (2006.01)
Patent
CA 2386942
GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have structure (I): wherein Ar, A, B, Q, R1, R2, R3a, R3b, R6, R7 and m are as defined herein, including stereoisomers, prodrugs and pharmaceutical acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.
L'invention concerne des antagonistes du récepteur de la GnRH, utiles dans le traitement de diverses conditions liées à l'hormone sexuelle chez l'homme et la femme. Les composés de la présente invention sont représentés par la formule (I) dans laquelle Ar, A, B, Q, R¿1?, R¿2?, R¿3a?, R¿3b?, R¿6?, R¿7? et m sont tels que définis dans la présente invention et comprennent des stéréoisomères, des prodrogues, et des sels pharmaceutiquement acceptables de ces derniers. L'invention concerne également des compositions renfermant un composé de cette invention combiné à un excipient pharmaceutiquement acceptable, ainsi que des méthodes d'utilisation de ces compositions, destinées à antagoniser l'hormone libérant de la gonadotropine (GnRH) chez un sujet en présentant le besoin.
Chen Chen
Connors Patrick J. Jr.
Gao Yinghong
Gross Timothy D.
Guo Zhiqiang
Gowling Lafleur Henderson Llp
Neurocrine Biosciences Inc.
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