Gonadotropins with non-native disulfide bridges

Details Gonadotropins with non-native disulfide bridges Gonadotropins with non-native disulfide bridges

C - Chemistry, Metallurgy

07

K

C07K 14/59 (2006.01) A61K 38/24 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2188508

The present invention relates to gonadotropins consisting of an .alpha. and .beta. subunit, said gonadotropins comprising non-native disulfide bridges, preferably non- native intersubunit disulfide bridges. The gonadotropins according to the invention have improved stability. The present invention furthermore provides for pharmaceutical compositions comprising said gonadotropins.

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