Goodpasture's syndrome model mouse

Details Goodpasture's syndrome model mouse Goodpasture's syndrome model mouse

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A01K 67/027 (2006.01) A61K 45/00 (2006.01) A61P 11/00 (2006.01) A61P 13/12 (2006.01) C12N 15/09 (2006.01) C12N 15/12 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/564 (2006.01)

Patent

CA 2375921

The present invention provides a non-human model animal of Goodpasture' s syndrome that contributes to the treatment of Goodpasture's syndrome where the development of therapy had been delayed due to the lack of adequate disease models , a method for screening a remedy for Goodpasture' s syndrome by using the model animal, and a method for diagnosing Goodpasture's syndrome at the early stage. A Goodpasture's syndrome model mouse is constructed by immunizing immunoglobulin Fc .gamma. receptor IIB knockout mouse with type IV collagen, thereby inducing Goodpasture's syndrome. Moreover, a remedy for Goodpasture's syndrome is screened by administration of test substances to the Goodpasture's syndrome model mouse, followed by evaluating the severity of the expression of Goodpasture' s syndrome as an index, such as diffuse alveolar hemorrhage, glomerulonephritis, the appearance of antikidney glomerular basement membrane antibody, and the like.

Cette invention a trait à un modèle animal du syndrome de Goodpasture contribuant au traitement de cette maladie dont le développement de la thérapie a été retardé du fait du manque de modèles adaptés. L'invention porte également sur une méthode de criblage de remède contre le syndrome de Goodpasture utilisant le modèle animal ainsi que sur une méthode de diagnostic de ce syndrome à un stade précoce. On immunise une souris présentant une déficience du récepteur IIB membranaire du fragment fc de l'immunoglobuline (fc gamma ) à l'aide de collagène de type IV et ce, afin d'induire le syndrome de Goodpasture. Cette opération permet de produire un modèle murin du syndrome de Goodpasture. On administre ensuite des substances d'essai au modèle murin et l'on procède au criblage d'un remède contre le syndrome de Goodpasture d'après l'évaluation de la gravité de l'expression dudit syndrome (c'est-à-dire hémorragie alvéolaire diffuse, glomérulonéphrite, apparition d'anticorps membrane basale glomérulaire antirénal, etc.).

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