C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/00 (2006.01) A61K 38/19 (2006.01) A61K 39/00 (2006.01) A61K 39/12 (2006.01) A61K 39/21 (2006.01) A61K 39/38 (2006.01) A61K 49/00 (2006.01) C07K 14/00 (2006.01) C07K 14/16 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C07K 17/00 (2006.01) C12N 15/85 (2006.01) G01N 33/50 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2267662
A gp120 conformational binding site that is formed by the binding of gp120 and CD4 which permits binding of the complex to the chemokine receptors is disclosed. Binding assays which permit the ready screening for molecules which affect the binding of gp120 and the chemokine are taught as well as specific targets for affecting the binding.
Cette invention se rapporte à un site de liaison conformationnel de la glycoprotéine gp120, formé par la liaison de gp120 et CD4 qui permet la liaison du complexe aux récepteurs de la chimiokine. L'invention se rapporte également à des techniques de liaison qui permettent un criblage aisé de molécules qui modifient la liaison de gp120 et de la chimiokine, ainsi qu'à des cibles spécifiques destinées à modifier la liaison.
Gerard Craig
Gerard Norma
Newman Walter
Sodroski Joseph
Wu Lijun
Children's Medical Center Corporation
Dana-Farber Cancer Institute Inc.
Leukosite Incorporated
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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