Gp120 specific antigens and uses thereof

Details Gp120 specific antigens and uses thereof Gp120 specific antigens and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/16 (2006.01) A61K 31/715 (2006.01) A61K 39/00 (2006.01) A61K 39/21 (2006.01) A61K 39/295 (2006.01) A61P 31/18 (2006.01) C07K 1/00 (2006.01) C07K 1/107 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/375 (2006.01) C07K 14/505 (2006.01) C07K 16/00 (2006.01) C07K 16/10 (2006.01) C08B 37/00 (2006.01)

Patent

CA 2508539

The present invention provides compounds having formula (I): wherein Rl, R2A, R2B, R3, R4, W1 , W2 and W3 are as defined herein; and additionally provides methods for the synthesis thereof, compositions thereof, and methods of use thereof in the treatment of HIV, methods for the prevention of HIV, and methods for inducing HIV-specific antibodies in a subject, comprising administering to a subject in need thereof, an effective amount of any of the inventive compounds as disclosed herein, either in conjugated form or unconjugated and in combination with a suitable immunogenic carrier. In another aspect, the invention provides an antibody or antibody fragment which binds specifically to a gp 120 glycan or glycopeptide of the invention.

L'invention concerne des composés de formule (I), dans laquelle R?l¿, R?2A¿, R?2B¿, R?3¿, R?4¿, W?1¿, W?2¿ et W?3¿ sont spécifiés dans la description. L'invention concerne également des procédés de synthèse desdits composés, leurs compositions, et leurs procédés d'utilisation dans le traitement du VIH, des méthodes de prévention du VIH, et des procédés pour induire des anticorps spécifiques au VIH chez un sujet. Ce procédé comprend l'administration à un sujet en ayant besoin, d'une quantité efficace des composés de l'invention, soit sous forme conjuguée, soit sous forme non conjuguée et en combinaison avec un support immunogénique approprié. Dans un autre aspect de l'invention, l'invention concerne un anticorps ou un fragment d'anticorps qui se fixe de manière spécifique à un glycane gp120 ou glycopeptide de l'invention.

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