Gp354 nucleic acids and polypeptides

Details Gp354 nucleic acids and polypeptides Gp354 nucleic acids and polypeptides

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2413986

An isolated polynucleotide encoding a novel immunoglobulin superfamily member named GP354 is provided. GP354 has a predicted single membrane spanning domain and five immunoglobulin (Ig) domains in the extracellular portion of the protein. The protein structure and tissue distribution of GP354 indicate that it plays a role in cell-cell recognition, binding, signaling and adhesion events in the pancreas and central nervous system (CNS). Provided by the invention are isolated GP354 related polynucleotides and polypeptides, vectors, and host cells comprising any of the above, antibodies directed to GP354, cells which produce such antibodies, and related diagnostic and therapeutic methods.

L'invention concerne un polynucléotide isolé codant un nouveau membre de la superfamille d'immunoglobulines appelé GP354. GP354 présente un domaine transmembranaire unique prédit et cinq domaines d'immunoglobulines (Ig) dans la partie extra cellulaire de la protéine. La structure de la protéine et la distribution du tissu de GP354 indique qu'elle joue un rôle dans les événements de reconnaissance de cellule à cellule, de liaison, de signalisation et d'adhésion dans le pancréas et le système nerveux central (SNC). L'invention concerne les polynucléotides et les polypeptides isolés apparentés à GP354, les vecteurs, et les cellules hôtes comprenant un élément quelconque des éléments mentionnés ci-dessus, les anticorps dirigés contre GP354, les cellules qui produisent de tels anticorps, et les procédés diagnostiques et thérapeutiques associés.

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