Gpi-anchored cytokines

Details Gpi-anchored cytokines Gpi-anchored cytokines

A - Human Necessities

61

K

A61K 48/00 (2006.01) C12N 5/0783 (2010.01) A61K 31/7088 (2006.01) A61K 38/20 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07K 14/55 (2006.01) C12N 15/19 (2006.01) C12N 15/861 (2006.01)

Patent

CA 2458236

The present invention relates to immunogenic compositions for stimulating T cell proliferation and methods for enhancing therapeutic effectiveness of some traditional anti-cancer treatments. Specifically, local delivery of cytokines that target the plasma membrane of a cancerous cell exhibit more potent anti- tumor effects than systemic delivery of cytokines in soluble form. Figure 2 shows pulmonary metastasis images of untreated tumor cells with tumor cells treated with soluble IL-2 and tumor cells treated with GPI anchored IL-2.

La présente invention concerne des compositions immunogènes stimulant la prolifération des lymphocytes T, et des procédés renforçant l'efficacité de certains traitements anticancéreux. Plus particulièrement, l'apport local des cytokines ciblant la membrane plasmatique d'une cellule cancéreuse donne de meilleurs résultats antitumoraux que l'apport systémique de cytokines sous forme soluble.

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