A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C12N 15/12 (2006.01) C12Q 1/00 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2345088
The invention features assays for the identification of compounds useful for the modulation of body weight. Such compounds are useful for the treatment of obesity and cachexia. The methods of the invention involve cell-free and cell- based assays that identify compounds which bind to and/or activate or inhibit the activity of GPR10, a G protein-coupled receptor, followed by an in vivo assay of the effect of the compound on feeding behavior, body weight, or metabolic rate. The invention also features compounds which bind to and/or activate or inhibit the activity of GPR10 as well as pharmaceutical compositions comprising such compounds. In addition, the invention includes nucleic acid molecules comprising a nucleotide sequence encoding all or a portion of murine GPR10, polypeptides comprising all or a portion of murine GPR10, antibodies directed against murine GPR10, and animals harboring a murine GPR10 transgene (e.g., mice overexpressing murine GPR10).
L'invention porte sur des essais servant à l'identification de composés influant sur le poids et pouvant traiter l'obésité et la cachexie. Le procédé de l'invention comprend des essais avec ou sans cellules permettant d'identifier des composés se fixant à la GPR10 et/ou en activant ou inhibant l'activité et le récepteur couplé à la protéine G, suivi d'un essai in vivo sur les effets du composé sur le comportement alimentaire, le poids et le rythme métabolique. L'invention porte également sur lesdits composés se fixant à la GPR10 et/ou en activant ou inhibant l'activité. L'invention porte en outre sur des molécules d'acide nucléique comportant une séquence de nucléotide codant pour tout ou partie de la GPR10 murine, sur des polypeptides comportant tout ou partie de la GPR10 murine, sur des anticorps anti-GPR10, sur des animaux abritant le transgène de la GPR10 murine (par exemple des souris exprimant la GPR10 murine).
Gu Wei
Stricker-Kongrad Alain
Millennium Pharmaceuticals Inc.
Smart & Biggar
LandOfFree
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