Gpr119 receptor agonists in methods of increasing bone mass...

Details Gpr119 receptor agonists in methods of increasing bone mass... Gpr119 receptor agonists in methods of increasing bone mass...

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 31/4375 (2006.01) A61K 31/4439 (2006.01) A61K 31/4545 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/519 (2006.01) A61K 31/522 (2006.01) A61K 45/06 (2006.01) A61P 19/02 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01)

Patent

CA 2650399

The present invention relates to the use of GPR119 receptor agonists for treating or preventing a condition characterized by low bone mass, such as osteoporosis, and for increasing bone mass in an individual. The present invention further relates to the use of a GPR119 receptor agonist in combination with a dipeptidyl peptidase IV (DPP-IV) inhibitor for treating or preventing a condition characterized by low bone mass, such as osteoporosis, and for increasing bone mass in an individual. A GPR119 receptor agonist and the combination of a GPR119 receptor agonist and a DPP-IV inhibitor promote bone formation in an individual.

L'invention concerne l'utilisation d'agonistes du récepteur de GPR119 pour traiter ou prévenir un état se caractérisant par une masse osseuse failble, par exemple l'ostéoporose, et pour augmenter la masse osseuse chez un patient. L'invention concerne en outre l'utilisation d'un agoniste du récepteur de GPR119 en combinaison avec un inhibiteur de dipeptidylpeptidase IV (DPP-IV) pour traiter ou prévenir un état se caractérisant par une masse osseuse faible, par exemple l'ostéoporose, et pour augmenter la masse osseuse chez un patient. Un agoniste du récepteur de GPR119 et la combinaison d'un agoniste du récepteur de GPR119 et de l'inhibiteur DPP-IV favorisent la formation osseuse chez un patient.

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