G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/574 (2006.01) A01K 67/027 (2006.01) A61K 31/00 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) C12N 15/00 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2617353
The invention relates to the graded expression level of SNAIL gene or its expression products, as a marker of the capacity of epithelial and mesenchymal tumours and/or cancers for disseminating to other tissues or organs. The invention further relates to a transgenic non-human mammal comprising in its genome a transgene that comprises a nucleic acid sequence encoding the SNAIL protein, and the use of SNAIL as a marker of epithelial and mesenchymal tumours and/or cancers as well as in DNA damage-based diseases In addition, the invention relates to the use of SNAIL as a therapeutic and diagnostic target for said pathologies.
L'invention concerne un niveau d'expression gradué du gène SNAIL ou de ses produits d'expression. Ce niveau sert de marqueur de la capacité de développement de tumeurs épithéliales et mésenchymales et/ou de cancers, pour une dissémination sur d'autres tissus ou d'autres organes. L'invention concerne également un mammifère non humain transgénique comprenant, dans son génome, un transgène comprenant une séquence d'acide nucléique codant la protéine SNAIL. L'invention concerne également l'utilisation de SNAIL en tant que marqueur de tumeurs épithéliales et mésenchymales et/ou de cancers, ainsi que de maladies caractérisées par une lésion d'ADN. En outre, l'invention concerne l'utilisation de SNAIL en tant que cible thérapeutique et diagnostique pour les pathologies susmentionnées.
Perez-Mancera Pedro Antonio
Sanchez-Garcia Isidro
Voces Felipe
Gowling Lafleur Henderson Llp
Oncostem Pharma S.l.
Perez-Mancera Pedro Antonio
Sanchez-Garcia Isidro
Voces Felipe
LandOfFree
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