Gradient generation control for large scale liquid...

B - Operations – Transporting – 01 – D

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B01D 15/08 (2006.01) G01N 30/34 (2006.01)

Patent

CA 2046538

US-2060 ABSTRACT Precise gradient control is accomplished using a high flow three- way valve, appropriate mixing, and precise metering control. Gradient elution profiles are generated for flow rates above 100 ml/min. Control involves precise selection of two solvents, and correction factors for valve lag times and pump/valve synchroni- zations. The gradient is controlled simultaneously with other non-timed operations through a single microprocessor controller.

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