Graft materials and methods for staged delivery of bioactive...

A - Human Necessities – 61 – L

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A61L 27/36 (2006.01) A61L 27/54 (2006.01) A61L 27/60 (2006.01)

Patent

CA 2717619

Described, in certain aspects of the invention, are multilaminate medical graft products, as well as methods for preparing and using the same. An illustrative multilaminate medical graft product of the invention comprises a first layer of remodelable extracellular matrix (ECM) material bonded to a second layer of remodelable ECM material, wherein the first material layer is enriched with a growth factor relative to the second material layer. Such a remodelable ECM material may be comprised of submucosa from a warm-blooded vertebrate, for example, porcine small intestinal submucosa (SIS).

La présente invention concerne, dans certains aspects, des produits de greffe médicale multicouche, ainsi que des procédés de préparation et dutilisation de ceux-ci. Un exemple de produit de greffe médicale multicouche de linvention comprend une première couche de matériau de matrice extracellulaire remodelable (ECM) liée à une seconde couche de matériau dECM remodelable. La première couche de matériau est enrichie dun facteur de croissance par rapport à la seconde couche de matériau. Un tel matériau dECM remodelable peut être constitué dune sous-muqueuse provenant dun vertébré à sang chaud, par exemple dune sous-muqueuse dintestin grêle (SIS) de porc.

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