Graft rejection inhibitor and il-1 production inhibitor

Details Graft rejection inhibitor and il-1 production inhibitor Graft rejection inhibitor and il-1 production inhibitor

A - Human Necessities

61

K

A61K 31/495 (2006.01) C07D 215/38 (2006.01)

Patent

CA 2134880

ABSTRACT OF THE DISCLOSURE A rejection inhibitor for transplants containing a carbostyril derivative represented by following general formula or a salt thereof as the active ingredient, and an IL-1 production inhibitor containing said carbostyril derivative or salt thereof as the active ingredient. In said formula, R represents benzoyl which may be substituted by lower alkoxy; and the carbon-to-carbon bond between the 3- and the 4-positions of the carbostyril skeleton represents either a single or double bond. The rejection inhibitor can improve the percentage take of transplants and is utilizable in the transplatation of various organs. The IL-1 production inhibitor is efficacious for the prevention and treatment of diseases caused by the excessive production of IL-1, such as various inflammatory diseases, osteoporosis and myeloid leukemia.

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