C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/08 (2006.01) A61K 35/14 (2006.01) A61K 35/28 (2006.01) A61P 37/06 (2006.01) C12N 5/06 (2006.01) A61K 35/12 (2006.01)
Patent
CA 2356882
The development of graft versus host disease in a mammalian patient undergoing cell transplantation therapy for treatment of a bone marrow mediated disease, is prevented or alleviated by subjecting at least the T-cells of the allogeneic cell transplantation composition, extracorporeally, to oxidative stress, in appropriate dosage amounts, such as bubbling a gaseous mixture of ozone and oxygen through a suspension of the T-cells. The process may also include irradiation of the cells with UV light, simultaneously with the application of the oxidative stress. The oxidative stress induces reduced inflammatory cytokine production and a reduced proliferative response in the T- cells.
On empêche ou on ralentit la progression de la réaction du greffon contre l'hôte chez un sujet mammifère subissant une thérapie par transplantation cellulaire en vue du traitement d'une maladie transmise par la moelle osseuse, en soumettant au moins les lymphocytes T de la composition de transplantation cellulaire halogène, en position extracorporelle, à une contrainte oxydative, selon des dosages appropriés, par exemple par barbotage d'un mélange gazeux d'ozone et d'oxygène dans une suspension de ces lymphocytes T. Ce procédé peut également comporter l'exposition des lymphocytes à un rayonnement ultraviolet, en même temps que l'application de la contrainte oxydative. La contrainte oxydative entraîne une réduction de la production de cytokine inflammatoire et une réduction de la réaction proliférative dans les lymphocytes T.
Ridout & Maybee Llp
Vasogen Ireland Limited
LandOfFree
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