Gram negative bacteruria test

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/06 (2006.01) C07K 5/083 (2006.01) C12Q 1/04 (2006.01) G01N 33/579 (2006.01)

Patent

CA 1292175

ABSTRACT OF THE DISCLOSURE A screening method for the determination of 104 gram negative bacteria per milliliter of an undiluted urine sample and a unitary screening test device for the determination of at least 105 gram negative bacteria per milliliter of an undiluted urine sample. The method and test device make use of Limulus amebocyte lysate (LAL) and a synthetic substrate containing a chromogenic or fluorosenic leaving group capable of being cleaved by activated lysate. This screening method and unitary screening device provide a quick, convenient, inexpensive indication of the possible presence of a urinary tract infection caused by gram negative bacteria.

524153

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