Granular anhydrous dicalcium phosphate compositions suitable...

Details Granular anhydrous dicalcium phosphate compositions suitable... Granular anhydrous dicalcium phosphate compositions suitable...

C - Chemistry, Metallurgy

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B

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C01B 25/32 (2006.01) A61K 9/20 (2006.01)

Patent

CA 1260226

GRANULAR ANHYDROUS DICALCIUM PHOSPHATE COMPOSITIONS SUITABLE FOR DIRECT COMPRESSION TABLETING ABSTRACT OF THE DISCLOSURE A granular anhydrous dicalcium phosphate having a particle of a size sufficient for direct compression tablets and a surface area of greater than 5 meters2/gram can be direct compression tableted. This product can be prepared by dehydrating granules of dicalcium phosphate dihydrate of a particle size sufficient for direct compression tableting and sufficiently large to allow the dehydration of the granules without lumping and without fracturing a majority of the granules. The granules are heated at a temperature sufficient to form anhydrous dicalcium phosphate. The product is a granular anhydrous dicalcium phosphate exhibiting good compressibility, flowability and whiteness while being in an anhydrous state.

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