Granular preparation for mri

Details Granular preparation for mri Granular preparation for mri

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61K 49/18 (2006.01)

Patent

CA 2149343

ABSTRACT The present invention relates to a granular preparation for MRI obtained by granulating a viscosity-increasing agent together with a binder and if necessary, an vehicle, a disintegrant, etc., by the use of a fluidized-bed granulation method, and spraying ferromagnetic particles suspended in an aqueous solution of a viscosity-increasing agent or a binder for coating the granules or incorporating the suspension into the granules at the time of granulation to prepare bulky granules. The granular preparation according to the present invention does not undergo coagulation due to gelling at the time of suspending, and can be instaneously turned to a suspension having a uniformity and viscosity by mere stirring. Accordingly, the preparation method is simple and easy. Since it is a solid preparation, stability of the ferromagnetic particle is higher than that of an aqueous dispersion, is free from the problem of putrefaction by microorganisms and molds and is advantageous from the aspects of transportation and storage space. -31-

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