Granular sustained release preparation and production thereof

Details Granular sustained release preparation and production thereof Granular sustained release preparation and production thereof

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2537607

There is disclosed a novel sustained release granular resin-pharmaceutical composition comprising an ion exchange resin complexed with a pharmaceutical material wherein said complex is embedded into and on the surface of a diffusion barrier material. There is also disclosed a novel process for preparing the granulated complex wherein an aqueous granulating vehicle is employed to form the complex and the granulated product, thereby avoiding the use of coatings and large amounts of organic solvents in the process.

L'invention concerne une nouvelle composition pharmaceutique de résine granulaire à libération prolongée comprenant une résine échangeuse d'ions complexée avec une substance pharmaceutique, ce complexe étant incorporé dans une substance à barrière de diffusion et appliqué sur sa surface. L'invention concerne également un nouveau procédé destiné à préparer ce complexe granulé et consistant à utiliser un véhicule de granulation aqueux pour former le complexe et le produit granulé, ce qui permet d'éviter l'utilisation de revêtements et de grandes quantités de solvants organiques dans le procédé.

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