Granulates for multiparticulate controlled-release oral...

Details Granulates for multiparticulate controlled-release oral... Granulates for multiparticulate controlled-release oral...

A - Human Necessities

61

K

167/164

A61K 47/00 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2005992

Abstract Granulates for multiparticulate controlled-release oral compositions comprising biologically active substance in solid dispersion with an acid-resistance and/or release- limiting compound, the solid dispersion being mixed with water-insoluble carrier particles, and the preparation of such granulates, Preferred biologically active substance are corticosteroids, non-steroidal anti-inflammatory drugs and bismuth compounds. The granules have a preferred particle size of less than 1 mm.

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