Granulates of hexahydropyrazine derivatives which can be...

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A61K 31/495 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01) A61K 31/4985 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2260889

The present invention relates to the preparation of orally administrable granules of hexahydropyrazine derivatives by mixing the active compound in the presence of suitable solvents with hydrophobic carriers, if appropriate in the presence of auxiliaries, and converting the resulting mixture, if appropriate, into other ready-to-use forms.

L'invention concerne la préparation de granulats de dérivés d'hexahydropyrazine, administrables par voie orale. Le principe actif est mélangé en présence de solvants appropriés avec des excipients hydrophobes éventuellement en présence d'auxiliaires et le mélange obtenu est éventuellement transformé dans d'autres formes galéniques prêtes à l'emploi.

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