Granulatimide compounds as g2 checkpoint inhibitors

Details Granulatimide compounds as g2 checkpoint inhibitors Granulatimide compounds as g2 checkpoint inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/14 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) C07D 471/22 (2006.01) C07D 498/14 (2006.01) C07D 513/14 (2006.01) C07H 9/06 (2006.01) C07H 19/044 (2006.01) C07H 19/23 (2006.01)

Patent

CA 2232074

Compounds are provided that inhibit the G2 checkpoint in the cell cycle and are useful for sensitizing G1 deficient cancer cells to killing by DNA damaging agents. Compounds of this invention have the general formula: Image wherein W is selected from the group consisting of: Image Image Image Image Image Image

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