Granulatimide derivatives for use in cancer treatment

Details Granulatimide derivatives for use in cancer treatment Granulatimide derivatives for use in cancer treatment

C - Chemistry, Metallurgy

07

D

C07D 471/22 (2006.01) A61K 31/4188 (2006.01) A61K 31/437 (2006.01) A61P 35/00 (2006.01) C07D 487/14 (2006.01) C07H 9/06 (2006.01) C07H 19/23 (2006.01)

Patent

CA 2322790

Novel granulatimide compounds and pharmaceutical formulations thereof are provided. Compounds of this invention have the general formula: Image wherein are independently R or Z as defined below, or in combination G and G' is Ar1 as defined below; Ar1 is a monocyclic, bicyclic or tricyclic, fully or partially aromatic system containing five or six membered carbocyclic or, oxygen, nitrogen or sulphur containing heterocyclic rings, optionally substituted with R or Z; W is selected from the group consisting of formula (i); (ii) or (iii), wherein the structures are as follows:

L'invention concerne de nouveaux composés de granulatimide et des formulations pharmaceutiques de ceux-ci. Les composés de l'invention sont représentés par la formule (I) ou (II). Dans cette formule, F et F' représentent indépendamment R ou Z tels que définis ci-dessous, ou F et F' en combinaison représentent Ar1 tel que défini ci-dessous; Ar1 représente un système monocyclique, bicyclique ou tricyclique partiellement ou totalement aromatique, contenant des noyaux carbocycliques à cinq ou six éléments, ou de l'oxygène, de l'azote ou du soufre comprenant des noyaux hétérocycliques, éventuellement substitués par R ou Z; W est sélectionné dans le groupe constitué par les formules (i), (ii) ou (iii), les structures étant telles que ci-dessous.

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