Granule and preparation method thereof

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/16 (2006.01) A61K 36/00 (2006.01) A61K 47/04 (2006.01) A61K 47/34 (2006.01) A61K 47/38 (2006.01) A61P 1/16 (2006.01) A61P 3/10 (2006.01) A61P 9/10 (2006.01) A61P 25/00 (2006.01) A61P 31/00 (2006.01)

Patent

CA 2654414

A pharmaceutical granule whose shape is spherical or spherical like with bulk density of 0.6-1.3 g/ml and disintegration time of 0.5-5 minutes, which is prepared as follows: mother granules are filled into fluid bed as bed charge; an active pharmaceutical ingredient is prepared in suspension or solution whose viscosity is adjusted to 6.0-9.8 Mpa.S with viscosity modifier; then it is sprayed as slurry onto the surface of said mother granules to obtain final granule.

L'invention concerne un granulé pharmaceutique dont la forme est sphérique ou de type sphérique avec une masse volumique comprise entre 0,6 et 1,3 g/ml et un temps de désintégration compris entre 0,5 et 5 minutes. Ledit granulé est préparé de la manière suivante : des granulés mère utilisés comme charge de lit remplissent un lit fluidique; un ingrédient pharmaceutiquement actif est préparé dans une suspension ou dans une solution dont la viscosité est réglée à 6.0-9.8 Mpa.S avec un agent de modification de viscosité; puis il est pulvérisé sous forme de bouillie sur la surface des granulés mère afin d'obtenir un granulé final.

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