C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/27 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2064814
The invention provides a recombinant or synthetic receptor for granulocyte-macrophage colony-stimulating factor. (GM-CSF) and biochemical and/or biological equivalents, homologues, or derivatives thereof, The GM-CSF receptor is useful inter alia in treatment and diagnosis of GM-CSF related diseases, and in screening of agonists and antagonists of binding of GM-CSF to its cell-bound receptors. The invention further provides nucleic acid sequences encoding GM-CSF receptor, recombinant DNA molecules comprising these sequences, and transformed hosts carrying the recombinant DNA molecules, as well as antibodies directed against GM-CSF receptor, and pharmaceutical compositions comprising either the GM-CSF receptor or antibody thereto.
Gearing David Paul
Gough Nicholas Martin
King Julie Ann
Metcalf Donald
Nicola Nicos Anthony
Amrad Corporation Limited
Mccarthy Tetrault Llp
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