Grf analogs

Details Grf analogs Grf analogs

C - Chemistry, Metallurgy

07

K

530/7.1

C07K 7/00 (2006.01) A23K 1/16 (2006.01) C07K 14/60 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1271898

GRF ANALOGS ABSTRACT OF THE DISCLOSURE Human pancreatic GRF analogs which are extremely potent in stimulating the release of pituitary GH in mammals and which have the formula: Image wherein R1 is selected from the D- and L-isomers of Tyr, Phe and His, R10 is Tyr or Phe, R15 is Gly or D-Ala, R27 is selected from the group consisting of the D- and L-isomers of Ala, Nle, Ile, Leu, Met and Val, R28 is Ser or D-Ala, and Y signifies the carboxyl moiety of the amino acid residue at the C-terminal and is the radical -COOR,-CRO,-CONHNHR,- CON(R)(R') or -CH2OR, with R and R' being lower alkyl or hydrogen, provided however that when R1 is Tyr, R27 is other than Met. These peptides or biologically active fragments thereof, which will generally extend from the N-terminal to the vicinity of a residue between positions 27 and 32, as well as nontoxic salts of any of the foregoing, may be administered therapeutically to animals, including humans, and may be used diagnostically.

445092

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