Grf analogs v

Details Grf analogs v Grf analogs v

C - Chemistry, Metallurgy

07

K

530/7.1, 167/103

C07K 14/60 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1304193

GRF ANALOGS V ABSTRACT OF THE DISCLOSURE The invention provides peptides which are particularly potent in stimulating the release of pituitary GH in fish and amphibians and which have a substantial portion or all of the following sequence: His-Ala-Asp-Gly-R5- Phe-Asn-Lys-Ala-Tyr-Arg-Lys-Ala-Leu-Gly-Gln-Leu-Ser-Ala- Arg-Lys-Tyr-Leu-His-Thr-Leu-R27-R28-R29-R30-R31-Gly-R33- R34-R35-R36-R37-R38-R39-R40-R41-R42-R43-R44-Ser wherein R5 is Met, Leu, Val, Nva, Gln, Thr, Ile or Nle; R27 is Met, Leu, Val, Nva, Gln, Thr, Ile or Nle; R28 is Ala, Ser or Asn; R29 is Lys or Arg; R30 is Arg or Gln; R31 is Val or Gln; R33 is Gly or Glu; R34 is Gly, Arg or Ser; R35 is Ser or Asn; R36 is Met, Leu, Val, Nva, Gln, Thr, Ile or Nle; R37 is Ile or Glu; R38 is Glu, Gln or Arg; R39 is Asp, Arg or Gly; R40 is Asp, Ser or Ala; R41 is Asn, Arg or Lys; R42 is Glu, Phe, Ala or Val; R43 is Pro, Asn or Arg; R44 is Leu or Ala. A sequence beginning at the C-terminus and extending part way or all the way to residue R27 may be deleted; a 29-residue peptide beginning at the N-terminus may be preferred. These peptides, as well as their nontoxic salts, are considered to be particularly useful in aquiculture.

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